"Sorry, chaps, you're obsolete": that may as well have been the headline of an announcement that gripped the research community on Thursday, as the birth was revealed of the world's first mammal born to two mothers. The scientists removed three imprinted regions from the DNA of a female ESC and injected them into the egg of a female partner to produce offspring from two moms.
"One possible approach is using "epigenetic-editing" on haploid stem cells, essentially reprogramming the DNA of one parent so it looks like that of the opposite sex without altering any genetic sequence".
Using a mash-up of stem cells and cloning technology, a team in Beijing claims to have generated mice with same-sex parents. The mice were normal, lived to adulthood, and had babies of their own.
One advantage of using haploid ESCs is that even before the problematic genes are knocked out, they contain less of the imprinting programming that ultimately causes maternal- or paternal-specific genes to be expressed. They produced 29 live mice from 210 embryos.
They also deleted a number of "imprinted" genes from these cells, since such genes normally depend on being paired with a corresponding male gene to work properly. "The genomic imprinting that's found in gametes was 'erased, '" says Hu. The baby's cells then have 46.
A similar experiment using two male parents failed, however, the pups dying within days of being born.
The bipaternal mice pups only survived for 48 hours after birth. Similar results were achieved in 2011 but using a method that relied on a female intermediary produced from the first father's stem cells to mate with the second father.
He said, "To consider exploring similar technology for human application in the near future is implausible".
The researchers aren't entirely sure why this happened, although they are planning to develop their procedures and try again in the future. "The defects in bimaternal mice [shown in previous research] can be eliminated and bipaternal reproduction barriers in mammals can also be crossed".
This research was supported by the Strategic Priority Research Program of the Chinese Academy of Sciences, the National Basic Research Program of China, the National Key Research and Development Program, the National High Technology R&D Program, the National Natural Science Foundation of China, the Key Research Projects of the Frontier Science of the Chinese Academy of Sciences, National Postdoctoral Program for Innovative Talents, and the Strategic Collaborative Research Program of the Ferring Institute of Reproductive Medicine, Ferring Pharmaceuticals and Chinese Academy of Sciences.
Le recul est moins fort, mais toutefois marqué en Europe: Londres abandonne 1,84%, Bruxelles 1,78%, Paris 1,5% et Francfort 1,33%. La Bourse de Hong-Kong reculait de près de -4% une heure avant la clôture hier et perdait -3,19% à l'ouverture jeudi.
Trump said earlier this week that he thought the central bank was moving too quickly with a series of planned interest rate hikes. On Wednesday, the Dow plunged more than 830 points as investors anxious that rising interest rates might slow economic growth.
She insisted Evans has told the truth and disputed that she either showed Weinstein her breasts or misled investigators. Weinstein's defence lawyer later suggested, outside court, that Ms Evans should be criminally prosecuted for perjury.
Leonardo Jardim was sacked on Thursday with the club 18th in Ligue 1 , having won just one of their opening nine matches. Martinez has backed Henry to succeed at Monaco , and said: "Thierry is ready to take a club".
The Marine Corps and Air Force have confirmed the grounding of their F-35s is a precaution so the aircraft can be inspected. Mr DellaVedova said: " The primary goal following any mishap is the prevention of future incidents ".
The documentary that really brought the issues with The Simpsons' portrayal of Apu was aptly titled " The Problem With Apu ". The writing as on the wall for this to be addressed, though very few actually caught it beforehand.
He didn't say if he suspected any of the current crew - an American, a Russian and a German aboard the station. Cosmonauts Vladimir Titov and Gennady Strekalov separated the capsule and landed safely near the launchpad.
CNBC reported that Apple plans on debuting the revamped TV app with original content and new features in "early 2019". By creating a library of entirely family friendly content, Apple can stand apart from Netflix as something different.
The balloon release led many to believe that the party was a gender reveal party for Johnson's supposed pregnancy. Onlookers spotted a bunch of blue balloons let up in the air and immediately presumed she is pregnant with a boy.
Hubble placed in safe mode as gyro issues investigated
The remaining three gyros available for use are technically enhanced and expected to have significantly longer operational lives. Rachel Osten, deputy mission head for the Hubble Space Telescope , tweeted, "Very stressful weekend".
Stigma remains as world celebrates Mental Health Day
The major causes of early death of people with mental illness are cardiovascular disease, respiratory disease and cancer. Against this background, Wheeler said greater efforts must be made to "help young people build mental resilience".
Federer forced to battle again on way to Shanghai quarters
Fourth-seeded Alexander Zverev of Germany also advanced to the quarterfinals by pasting Alex de Minaur of Australia 6-1, 6-4. Open last month and looked in complete control as he won 34 of 40 points on his first-serve to book a place in the last 16.
Chute des Bourses européennes dans le sillage de Wall Street
La Bourse de Tokyo a clôturé en baisse de 3,89% et les Bourses chinoises ont ouvert ce jeudi sur un recul marqué, de plus de 3%. La directrice du FMI Christine Lagarde a justifié jeudi ces hausses de taux au vu du contexte économique actuel.
Kanye West Rambles Like Trump In White House Meeting
West, a Chicago native, said he and the president will discuss ways to combat the Windy City's ongoing gun violence epidemic. West said he was diagnosed with bipolar disorder, but then that he was misdiagnosed, and was simply sleep-deprived.