Coffee may reduce developing of Alzheimer’s, Parkinson’s

08 Novembre, 2018, 18:16 | Auteur: Yves Courtet

That hot cup of joe you require each morning may be doing more for your brain than giving it a burst of energy.

Your morning cup of coffee may protect you against developing both Alzheimer's and Parkinson's disease, scientists claim. The researchers wanted to investigate that which compounds are involved and how they may impact age-related cognitive decline.

"The caffeinated and de-caffeinated dark roast both had identical potencies in our initial experimental tests", said Ross Dr. Mancini, a researcher. However, as demonstrated in this study, the protective effect has not caffeine, and a substance contained in coffee.

The researchers found the strength of the coffee to be the same across all three blends, so they ruled out caffeine as the component behind the health benefits.

The new study highlights how a group of compounds known as phenylindanes, produced during the roasting of the coffee beans, actually stop two protein fragments common in Alzheimer's and Parkinson's, beta-amyloid and tau, from clumping together and misfolding. The researchers believe that these coffee antioxidants protect against the development of Alzheimer's and Parkinson's, because they have the potential to inhibit proteins beta-amyloid and Tau proteins that accumulate in the brain and cause damage, leading to the development of risky diseases.

For the study, reported in the journal Frontiers in Neuroscience, the team chose to investigate three different types of coffee - light roast, dark roast and decaffeinated dark roast.

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"So phenylindanes are a dual-inhibitor".

"The first time someone took up the study of interactions between phenylindane and proteins that cause adverse symptoms of Alzheimer's and Parkinson's". It means that drinking dark roasted would provide more phenylindanes and therefore, would be most effective in protecting brain function. "The next step is to investigate how useful this compound is and whether it is easy to enter the bloodstream or cross the blood-brain barrier".

'It's interesting but are we suggesting that coffee is a cure?

"Mother Nature is a much better chemist than we are and Mother Nature is able to make these compounds".

But more research is needed before it can translate into potential therapeutic options, they said. "Absolutely not", cautioned Weaver.

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