Black women with breast cancer have worse outcomes than white women
08 Décembre, 2018, 21:54 | Auteur: Yves Courtet
Centers for Disease Control and Prevention (CDC) revealed data which states that in the U.S. the cases of uterine cancer are getting enlarged and blackwomen are getting more diagnosed with it.
Uterine cancer is the fourth most common cancer and the seventh most common cause of cancer death among USA women.
"Importantly, the low-risk group had a 4% rate of distant recurrence in years 5-15 compared to 16% in the high-risk group, which suggests that EndoPredict can help select patients who can safely forgo extended endocrine therapy beyond five years", Filipits said in a statement. The disease claims the lives of about 40,000 people each year.
Uterine cancer is on the rise despite the decline of most other cancer diagnosis rates in the United States, according to a newreport from the U.S. Centers for Disease Control and Prevention (CDC).
Findings from the same multinational research, known as the TAILORx trial, were released in June showing that most women with early breast cancer don't benefit from chemotherapy. Treating them with chemotherapy and hormone therapy after surgery doesn't improve outcomes more than hormone therapy alone.
A second analysis gauged the test's ability to predict distant breast cancer recurrence up to 15 years. Ethnically, 79 percent were non-Hispanic, 9 percent were Hispanic and 12 percent were of unknown ethnicity.
The types, use and length of treatments were similar between both black and white patients and between Hispanic and non-Hispanic patients.
"In this study, women with a high EndoPredict score were four times more likely to experience a breast cancer recurrence setback", said principal investigator Martin Filipits, Ph.D., of the Institute of Cancer Research at the Medical University of Vienna, Austria.
"We inherit genes from our parents and the genes that metabolize drugs ... differ", Albain said.
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Also, because hormone therapy pill adherence was self-reported, she noted, the study authors don't know if black and white patients actually took the pills according to directions, or in the same way.
"Patients will tell me all the time they're taking their pills, and they're not taking their pills", Albain said.
The study was funded by the Breast Cancer Research Foundation, the American Society of Clinical Oncology, and other organizations.
"This study, in addition to previously published work in this area, establishes that oxybutynin is an effective drug for treatment of hot flashes in patients who have relative or absolute contraindications to hormone-based therapy", says Dr. Leon-Ferre.
"There's no doubt that the incidence and mortality of uterine cancer, specifically endometrial cancer, is higher in African-American women", he said.
"We have to chip away at it all, increase our understanding of disease differences and not lump [factors together] as much as we do", Partridge said.
"Ideally, such studies will simultaneously investigate BMI, body composition (adiposity, including location and muscle mass), clinical definitions of metabolic health, and circulating metabolic markers to determine whether BMI, fat mass (including location of fat), and metabolic markers all contribute to breast cancer risk, or whether risk is present only in those with specific fat distributions and/or metabolic profiles", Pimentel and co-authors wrote.
"The fact that oxybutynin does not interfere with the metabolism of tamoxifen is an important consideration for breast cancer survivors, as some of the most effective non-hormonal treatments for hot flashes are thought to potentially decrease the efficacy of tamoxifen", Leon-Ferre added.
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