End to insulin shots? Diabetes patients could take pill containing tiny needles
08 Février, 2019, 21:23 | Auteur: Yves Courtet
One of the most common diseases in the world is diabetes and some people suffering from the condition are insulin dependent. Vaccinations, insulin injections, or intravenous drips could one day be replaced by smart pills that inject the medicine directly into your stomach.
To try to meet this challenge, the researchers developed a capsule that contains a small needle that's made of compressed insulin. They also demonstrated that the device can be adapted to deliver other protein drugs.
The team, from Brigham and Women's Hospital and the Massachusetts Institute of Technology, says this localized approach is more pleasant to take, easier to carry around and less expensive than traditional injections.
Lead author Alex Abramson, a Ph.D. student in the department of chemical engineering at MIT, said, "The system had to be self-orienting".
Now, researchers at MIT have developed just that - so far, it's only been trialed in animals, but it's certainly an exciting start.
The tip of the needle is made of almost 100 percent compressed, freeze-dried insulin, using the same process used to form tablets of medicine. But Traverso said more research is needed to see how the stomach handles daily micro-injections over many months.
Next the team designed a micro-injector, like a needle only made of dried insulin compressed into a sharp point.
Once the pill reaches the stomach, water dissolves the disk, releasing the spring, and pushing out the to inject the stomach with the all-important insulin. So, they turned to an unlikely animal for inspiration: the leopard tortoise.
Friends Star Matthew Perry Sparks Concern With Tweet
In 2001, he checked back into a rehab facility to recover from his use of Vicodin, methadone, amphetamines, and alcohol. He said he spent three months in hospital seeking treatment. 'Three months in a hospital bed.
Doug Collins: 'Evil of Abortion' Key in Virginia Scandals
A blurb under one man's picture says: "He was known as the "Barracks Jew" having his fingers in the finances of the entire Corps". Thomas Norment listens to debate during the Senate session at the Capitol in Richmond , Virginia, Thursday, Feb. 7, 2019.
Les NTIC : avantages et inconvénients
En effet, avoir mille et une tâches à accomplir à la fois, ça peut avoir des effets négatifs. En effet, les travailleurs effectuent les tâches beaucoup plus rapidement tout en conservant leur qualité de vie.
The shape of the capsule is inspired by the leopard tortoise, found in Africa, which has a steep, domed shell that allows it to right itself if it rolls onto its back. The researchers used computer modeling to come up with a variant of this shape for their capsule, which allows it to reorient itself even in the dynamic environment of the stomach.
When tested in pigs, the device worked consistently and was able to deliver equivalent doses of insulin to those required by someone with diabetes. The insulin needle takes about an hour to dissolve into the bloodstream.
The researchers describe the capsule as "about the size of a pea" and made from biodegradable polymer and bits of stainless steel. In tests in pigs, the researchers said they were able to deliver five milligrams of insulin - comparable to the amount that a patient with type 2 diabetes would need to inject.
After the capsule releases its contents, it can pass harmlessly through the digestive system.
The researchers are now working on improving their capsule and determining how best to manufacture it.
"Our motivation is to make it easier for patients to take medication, particularly medications that require an injection", Traverso says.
The research was funded by Novo Nordisk, the National Institutes of Health, a National Science Foundation Graduate Research Fellowship, Brigham and Women's Hospital, a Viking Olaf Bjork Research Scholarship, and the MIT Undergraduate Research Opportunities Program.
She says she walked him back to his hotel room one night where " consensual kissing quickly turned into a sexual assault ". White actors wearing blackface acted like buffoons in one of the first American epic movies, 1915's "Birth of a Nation".
A range figure of 400 miles was quoted by Aston, alongside a rapid wireless charge of the battery pack in just 15 minutes. At the time, Aston Martin execs promised production cars as varied as sedans, coupes, and SUVs.
Like many similar startups, Aurora is focused on developing a driverless system rather than producing full-fledged cars. Embark also received significant funding from Sequoia previous year and has raised $47 million overall to date.
Guenter Butschek, CEO and MD, Tata Motors, said "Fiscal year 2019 so far has been a challenging period for the industry". At the same time, investment in new models, electrification and other technologies remains high.
Smriti Mandhana's fastest T20 half-century went in vain as India lost the 1st T20I against New Zealand . Replays soon showed a white blot on HotSpot as the ball passed the bat, suggesting an inside edge.
Nul doute qu’elle offrira à Mika la meilleure option pour poursuivre sa carrière dans le sport automobile. Et il n'est pas Andrei Arshavin, pour répondre à la question sur les attentes facilement et naturellement.
A Muslim inmate was put to death in Alabama on Thursday for the 1995 killing of a 15-year-old girl after the U.S. Ray's attorneys had also asked in legal filings to stay the execution on other grounds.
Le milliardaire a farouchement refusé et a publié jeudi le contenu des courriers d'AMI , dénonçant avec virulence ce "chantage". A la suite de l'ouverture de cette enquête, AMI aurait alors contacté Jeff Bezos pour le convaincre d'y mettre un terme.
Crucially for Expedia and Booking, the CMA has not made a finding on whether their sites' practices were illegal. When booking through online travel sites, consumers shouldn't be subjected to pressure selling .
Comment devenir webmaster?
Il est amené à rajouter des textes, des images, des vidéos. Il procède également à l’analyse du trafic.
Liverpool Star Urges Reds To Go On Winning Run
But Klopp has stressed that the mood of Liverpool's title charge on the outside is much different to the one inside Melwood. It was not that long a break but it's a muscle injury so we need to have another look today.
Twitter 1Q revenue forecast misses estimates
Monthly active users (MAUs) averaged 321 million in the fourth quarter which represents a decrease of 9 million from a year ago . Jack Dorsey , Twitter's chief executive, said "2018 is proof that our long-term strategy is working".