Second seed Kevin Anderson, runner-up at Wimbledon previous year, went down 6-1, 4-6, 6-4 to Gilles Simon while another Frenchman, Nicolas Mahut, put paid to the hopes of three-times Grand Slam champion Stan Wawrinka.
Edmund, 24, saved six match points in the 12th game but the Greek clinched victory with a backhand down the line.
His weariness at the end of match - which he freely admitted to in a post-match interview with TV presenter John Inverdale - was understandable given he had started the day still needed to put in half an hour's work to get past British number one Kyle Edmund. The two men edged with relative ease to 5-5, and after another hold from Tsitsipas, it was down to Edmund to take it to a tie-break.
The world number 30 was unable to convert a break point in the seventh game and it proved costly as Tsitsipas eventually ended his resistance by taking his seventh match point in a gripping final game. "I've been watching it as a kid, following this tournament for many years now", Tsitsipas told the BBC, per Metro UK.
And when they returned this morning, the British No 1 knew a fast start was key to any comeback.
The qualifier, ranked down at 191 but always a threat on grass, had just dropped serve early on and made a decision to send down a practice delivery that clipped the ballgirl in the head as she went about her duties at the back of the court. "I didn't play my best, but survived".
But it was in the bottom half of the draw that the upsets quickly emerged.
Defending champion Marin Cilic was cut down to size by Argentine Diego Schwartzman in the second round at the Queen's Club Championships on Thursday as the rain that has dogged the tournament finally relented.
The big-serving 33-year-old South African - last year's Wimbledon runner-up - has missed most of the season because of an elbow injury and his rustiness told as Simon ran out a 6-1 4-6 6-4 victor. He came from behind to beat Chardy 4-6, 7-6 (0), 7-6 (4). He will play the victor of the other remaining second-round match between Felix Auger-Aliassime and Nick Kyrgios, which also continued into a deciding set, in the quarter-finals.
Compare odds and from multiple different online sportsbooks and shop for the best lines at our new MLB Odds & Betting Page . A former Pittsburgh Pirate, Nova is making his sixth career start at Wrigley Field, where he is 3-1 with a 5.13 ERA.
Norman says she chose not to order any food that evening but some of her friends did and their meals were comped. We look forward to reopening soon to once again serve our guests in the Westchester area'.
As ocean waters have warmed over the past two decades, they have melted the floating ice that once shielded the outlet glaciers. Each of the three emissions scenarios used in the study produced different patterns of ice retreat across Greenland.
Only around 20% of respondents to a Bank of England survey think Brexit uncertainty will be resolved by the end of this year. Being on track has enabled the Bank to keep rates frozen and not have to raise rates to maintain a grip on prices.
C'est le jury final qui aura la tâche de départager les deux finalistes et d'élire le grand vainqueur de l'émission de la Une. Vendredi 21 juin, c'est Maud qui l'a emporté avec 7 voix contre 6 pour Cindy , la candidate qui attend un heureux événement.
Biden formed a political alliance with Eastland, a diehard, last-ditch defender of white supremacy, to support his legislation. Most recently, Biden remained defiant after making comments about how he was able to work well with former Sens.
Democrats were also concerned about possible conflicts of interest as she holds extensive investments in fossil fuels. Craft told the committee that all of her travel was approved in advance and complied with government policies.
When a place offers a discount coupon for following it, a little badge with a price tag will appear on the Follow button. There'll also be an opportunity to order assets like stickers that promote their Google profile.
And the Italian club are believed to be front-runners for the striker - and could offer Mauro Icardi as part of the deal. The striker, 26, and his agent Federico Pastorello want to treat United with more class.
A jury has reached a verdict in the civil trial between National Football League star Drew Brees and a San Diego-based jeweler. Moradi's attorney, Peter Ross, says the Houston-based jeweler the Breeses consulted was a "con man" who scammed the couple.
Mosquitoes pick up the virus by feeding on an infected bird and then transmit it by biting you. The most common diseases spread by mosquitos in OH include West Nile and La Crosse viruses.
Freddie Mercury et ses chansons inoubliables
Rien de tel pour saisir toute la puissance et la magie de du légendaire chanteur à la voix reconnaissable entre mille! La vidéo pour la chanson a été filmée en trois heures un mardi au Dominion Theatre.
Summer kicks off with free cones at Dairy Queen
In order to get your cone, you'll have to download the Dairy Queen app (which is free for both Apple and Android phones ). Dairy Queen is marking the first official day of summer by giving away free ice cream - with any purchase.
Birthday Boy Thalapathy Vijay: Fans Set Twitter Ablaze
The team has used multiple high-end cameras and powerful lights to recreate the real football matches, as seen on television. Produced by Archana Kalpathi, under the banner of AGS Entertainments, the film is slated for a Diwali release.
IIHS: Motorists confused by semi-autonomous technology
IIHS took a look at the instrument cluster of a 2017 Mercedes-Benz E-Class with the Drive Pilot system for this goal . Systems designed to make driving more automated have created a cloud of confusion for drivers, the IIHS found.
Celtic start Champions League campaign against Sarajevo
The victor of the tie will be guaranteed a third round Europa League qualifier, while the loser will go into the second round. The draw at UEFA HQ in Switzerland will see Dundalk seeded in Group 3 , while Linfield are unseeded in the same pot.
Juventus 'close in on signing of £62m Matthijs de Ligt'
Players like Eden Hazard, Luka Jovic, Ferland Mendy, Eder Militao and Rodrygo have already joined the Santiago Bernabeu side. That came after his fellow Holland global Frenkie de Jong signed for the Spanish champions in a £65m deal.