Measles Virus Infection Destroys Immune System Memory

08 Novembre, 2019, 08:09 | Auteur: Yves Courtet
  • Chalkboard eraser

The childhood disease measles causes long-term damage to the immune system which makes patients more vulnerable to other diseases, according to new research which used information gleaned from orthodox Dutch Protestants who don't vaccinate their children.

Researchers writing in the journal Science found that when kids get measles, it can cause "amnesia" in the immune system.

Doctors have long known that people temporarily experience weakened immunity after measles.

One of the reasons the virus is so risky is that it attacks our immune system, making us more vulnerable to other infections, possibly for years. The researchers then compared these samples with the blood of 115 uninfected children and adults using the VirScan system, a tool that detects antiviral and antibacterial antibodies in the blood.

The authors of the study, who include a team from the Wellcome Sanger Institute in Cambridge, say children denied the MMR jab could even lose their immunity to illnesses they have been vaccinated against, such as whooping cough, diphtheria and tuberculosis. The vaccine's emergence cut measles cases by 80% between 2000 and 2017 and is credited with saving 21.1 million lives.

But scientists, who read genetic "barcodes" for these cells so they could recognise them in the 26 children, found they were hugely depleted after measles. Measles infection erases big sections of the text, an effect sometimes called immune amnesia.

"We showed that measles-like viruses can delete pre-existing flu immune memory from ferrets", says Paul Kellam, an author on one of the new papers. Stores of the cells, created in the bone marrow, were depleted by the virus - an effect, they said, that provides a biological explanation for why child deaths not related to the measles increase for several years after a measles outbreak.

The new findings highlighted the necessity of widespread vaccination.

Choose Splento For Your Corporate Event Photography Solution in the US
You may also have an upcoming corporate event anywhere in the US that you wish to make a permanent visual record of. As well as corporate event photography, Splento can also put you in touch with a headshot photography specialist.

Amazon just confirmed its Black Friday device deals
It's important to know when you can find the best deals , and surprisingly, it isn't always necessarily on Black Friday . Customers who purchase a Google Pixel 4 or Pixel 4 XL from Target will also receive a $300 Target gift card .

Fils de légende de la Formule 1 a dépassé son père
Nul doute qu’elle offrira à Mika la meilleure option pour poursuivre sa carrière dans le sport automobile. Et il n'est pas Andrei Arshavin, pour répondre à la question sur les attentes facilement et naturellement.

Mina and his colleagues analyzed blood samples from 77 unvaccinated children from 3 schools in the Netherlands, taken before and after a measles outbreak in 2013. By protecting against the pathogen, the vaccine prevents the body from losing or "forgetting" its immune memoryand preserves its resistance to other infections.

He recommended that people vaccinated against other diseases who contract the measles should consider getting another round of shots. In addition, three co-authors are inventors on a patent application filed by Brigham and Women's Hospital that covers the use of the VirScan library to identify pathogen antibodies in blood.

"Our study has huge implications for vaccination and public health as we show that not only does measles vaccination protect people from measles, but also protects from other infectious diseases".

"Imagine that your immunity against pathogens is like carrying around a book of photographs of criminals, and someone punched a bunch of holes in it", epidemiologist Michael Mina told the Harvard Gazette.

A separate study, published Thursday in Science Immunology, supported the findings. And if these are the consequences of measles in a high-income nation where death from the virus is rare, it's even more important this research be conducted in places where the disease is commonplace, he says. But two months after recovering from measles, the children had lost on average 20 percent of their usual antibody mix. The findings also serve as a reminder that this year's record-breaking measles outbreaks in the USA will have lingering effects, Schaffner added. The vaccine equips the body with an arsenal of anti-measles antibodies, just as the virus itself would, he said.

Researchers then tested this "immunological amnesia" directly in ferrets, showing that infection with a measles-like virus reduced the level of flu antibodies in ferrets that had been previously vaccinated against flu. The phone check bounce back to typical levels once the contamination clears, yet and still, after all that, the influenced individual may stay immunosuppressed for a considerable length of time thereafter - fundamentally, the measles infection changes individuals into exposed targets for different infectious diseases.

Omer said there is already a wealth of good science supporting the importance of measles vaccines and yet a small but vocal proportion of the population does not find it persuasive.

"This study yet again dispels the risky myths perpetuated by homeopaths and other "natural" healers who claim that exposure of infants to natural infection is important to "strengthen" children's immune systems", writes endocrinologist Nikolai Petrovsky from Flinders University.


  • La Juventus privée de Matthijs de Ligt à Moscou — Ligue des champions

    La Juventus privée de Matthijs de Ligt à Moscou — Ligue des champions

    Adrien Rabiot débutera ce mercredi dans le onze de départ de la Juventus . Mon instinct a pris le dessus et j'ai poussé le ballon dans le but.
    Italie - Naples confiné cette semaine, Carlo Ancelotti subit

    Italie - Naples confiné cette semaine, Carlo Ancelotti subit

    Une colère qui pourrait également relancer la rumeur d'une arrivée du joueur au PSG dans les prochains jours. Carlo Ancelotti n'approuve pas la décision présidentielle: "Je suis en désaccord avec le club".
    A.J. Green Experiences Setback On Ankle, Out Indefinitely

    A.J. Green Experiences Setback On Ankle, Out Indefinitely

    The ninth-year receiver said he doesn't know how long he will need to stay off the ankle as he continues the rehab process. There's a decent chance that the winless Cincinnati Bengals might decide to simply shut down wide receiver A.J.
  • Sears to close 96 more stores; gets cash lifeline

    Sears to close 96 more stores; gets cash lifeline

    Lampert, through his hedge fund ESL Investments Inc, has contributed a significant portion to the new financing, the people added. Sears also owns Kmart discount stores, 45 of which will shutter during the December closings, one of the people said.
    Carrie Fisher in The Rise of Skywalker Appears For 8 Mins

    Carrie Fisher in The Rise of Skywalker Appears For 8 Mins

    They grabbed every frame and analyzed it. and then reverse-engineered it and [got] it into the story the right way. Billie Lourd has detailed her life growing up as the daughter of the late Star Wars actress, Carrie Fisher .
    Leroy Merlin en Russie est au bord du scandale ?

    Leroy Merlin en Russie est au bord du scandale ?

    La part du réseau Leroy Merlin sur le marché russe de "l'équipement ménager" approche les 20%. Beaucoup d'entre eux se plaignent des manifestations de corruption et des violations de l'éthique des affaires.
  • Le Brésil accuse un pétrolier grec — Marée noire

    Le Brésil accuse un pétrolier grec — Marée noire

    Les autorités brésiliennes ont dit poursuivre les investigations pour déterminer si le déversement est volontaire ou accidentel. Les premières traces de pétrole ont été découvertes en mer, le 29 juillet, à 700 kilomètres des côtes.

    Comment devenir webmaster?

    Il est amené à rajouter des textes, des images, des vidéos. Il procède également à l’analyse du trafic.

    Votre voiture doit être dans un état impeccable

    En ce qui concerne la sécurité, le choix des pneus parfaitement adaptés est extrêmement. Mais tout d’abord, vous devez savoir où trouver les pièces compatibles avec votre voiture.
  • Geodrill says two employees killed in Burkina Faso attack

    Geodrill says two employees killed in Burkina Faso attack

    The company blamed "armed bandits" for last year's attacks, and subsequently reinforced its armed escorts. The incident took place between Fada and Boungou in East Region of Burkina Faso on Wednesday.
    United States  captain Woods will play in Presidents Cup

    United States captain Woods will play in Presidents Cup

    Everyone is required to play in at least one match ahead of the Sunday singles, meaning Woods only has to play twice. He went 2-1, including a victory in singles, as the United States crushed the global team 20-12.
    Enquête sur des échauffourées entre police et des magistrats en grève — Algérie

    Enquête sur des échauffourées entre police et des magistrats en grève — Algérie

    Des échauffourées s'en sont suivies entre les magistrats protestataires et les forces de l'ordre. Djarir a considéré que le mouvement des magistrats ne s'apparente nullement à une grève.


Nouvelle journée émaillée d'incidents, six blessés dans une violente bagarre — Hong Kong
Dans un enregistrement audio qui a fuité en septembre, Mme Lam avait confié qu'elle démissionnerait si elle en avait le " choix ". Selon Willy Lam, un expert en politique chinoise basé à Hongkong, Pékin montre qu'il la soutient "pour le moment ".

Jeff Sessions Expected To Announce Run For His Old Senate Seat
Sessions referenced his departure from Trump's administration in a campaign announcement video published Thursday night. Jones defeated Moore in 2017, becoming the first Democrat to win election to the Senate from Alabama in 25 years.

BBC3 says shantay to RuPaul's Drag Race
The current season's finale airs at 8 p.m. on Thursday, November 21, exclusively on BBC iPlayer in the United Kingdom . The BBC and programme makers World of Wonder have officially announced a second series to air on BBC Three next year.

Juul stops selling mint-flavored vapes
Leading e-cigarette company Juul has halted sales of its popular mint flavor tobacco products, the company announced on Thursday. It stopped selling popular fruit and dessert flavors in stores a year ago , and last month , stopped selling them online, too.

Warren, Buttigieg make gains in new national poll
The new survey of 1,003 adults was conducted between October 27 and October 30, with a margin of error of 5.5 percentage points. Former Vice President Joe Biden is holding regular among the many Democratic presidential hopefuls however Sen.

Kristen Bell returning to narrate ‘Gossip Girl’ reboot on HBO Max
The Gossip Girl reboot will be written by original show creator Joshua Safran , producer of Quantico . The actress, 39, voiced the mysterious narrator during the series' original run from 2007-2012.

Hawaii man dies after falling down lava tube in his garden
An elderly man fell to his death after slipping down a "lava tube" in his yard in Hawaii , local police said Wednesday. An autopsy performed the following day determined that the victim died as a result of injuries from the fall.

People puzzled by peculiar texts, and no one can say why
Gergs also said Valentine's Day messages were likely affected because the amount of texts sent on that day is "abnormally high". Text messages received overnight on Wednesday caused confusion, misunderstandings and even alarm for some recipients.

Triste fin pour Antony Auclair
Il s'est infligé sa blessure en première demie et il a continué à jouer pour aider son équipe à essayer de l'emporter. Il était aussi considéré comme le meilleur bloqueur de l'équipe à cette position.

Revivez la défaite de Rennes contre Cluj — Ligue Europa
Notamment Arlauskis , qui multiplie les parades de grande classe, comme à la 77e minute sur une très grosse frappe de Bourigeaud. Le Stade rennais ira défier le CFR Cluj dans le cadre de la 4e journée de Ligue Europa .