HIV experts ‘optimistic’ about vaccine, potentially in next two years

04 Décembre, 2019, 19:23 | Auteur: Yves Courtet
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In a separate statement given by Dr. Buchbinder she said "We have three vaccines now being tested in efficacy trials, and it takes quite a bit to actually be promising enough in the earlier stages of trials to move you forward into an efficacy study", Once the HIV vaccines pass the efficacy stage, this would hopefully end the epidemic problem of the society most especially those who are carrying the virus. This vaccine is different from the first: it is a mosaic vector vaccine, that is, it includes fragments of proteins that contain all the main strains of the virus.

In addition to offering higher safety than the RV144 routine, HVTN 702 has been tailored to the HIV subtype that predominates in southern Africa (HIV-1 clade C). Of the three HIV vaccines now progressing through trials, one is built specifically to target a subtype of the virus that has devastated portions of southern Africa, while the other two are created to combat a broad range of HIV variants.

Dr. Susan Buchbinder, a chair of the Imbokodo and Mosiaco trials told NBC News that this is "perhaps one of the most optimistic moments we have been in" in regards to HIV research.

Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, said that even if a vaccine is only 50% effective it would be worth deploying alongside other prevention methods such as PrEP, to prevent new infections, and TasP (Treatment as Prevention), to ensure those living with HIV reach undetectable - and thus untransmittable - status.

Even efficient vaccine can be "an incredible breakthrough" and "would actually have the ability to vary the trajectory of the epidemic", she mentioned. Imbokodo uses "mosaic" immunogens, which are "vaccine components created to induce immune responses against a wide variety of global HIV strains", according to the National Institutes of Health.

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The Imbokodo trial started in 2017 in five southern African nations and results are expected in 2021. They are nearly identical, but with slightly different formulations. The third trial, Mosaico, is similar to Imbokodo, and will be undergoing clinical trials at 57 sites in the United States, Latin America, and Europe.

Left untreated, this results in AIDS - the identify for a sequence of lethal infections which the weakened immune system cannot deal with. HIV experts say a vaccine needs to be at least 50 per cent effective to be a "game changer" in combating numbers of cases.

Medical doctors can already dish out pre-exposure prophylaxis (PrEP), a each day capsule that folks at very excessive danger can take to forestall getting HIV.

HVTN 702 accomplished enrollment this summer season, and medical outcomes are anticipated in late 2020 or early 2021.

Research ahead of this year's World AIDS Day shockingly showed that 40 per cent of those surveyed think there is a cure for HIV. Results from Imbokodo are expected in 2021, and results from Mosaico are expected in 2023.

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