China CRISPR baby experiment may have created "unintended mutations"

05 Décembre, 2019, 02:06 | Auteur: Yves Courtet
  • He Jiankui’s experiment failed to recreate HIV resistant genes in twins Lulu and Nana

He Jiankui, a Chinese biophysics researcher, earlier claimed to have successfully performed gene-editing on twins Lula and Nana and immunised them against HIV.

It remains unclear whether Chinese scientist He Jiankui's gene-editing on twins born a year ago, meant to immunise them against HIV, has been successful in its intended objective.

Several excerpts from the manuscript were released by the MIT Review for identifying how He Jiankui, the scientist behind this experiment, ignored the scientific norms and used unethical methods on the twins.

However, at the time, it was not clear whether the experiment had even been successful at immunizing the girls against HIV because the researchers had not reproduced the precise gene mutation that is known to confer protection. "Public health initiatives, education, and widespread access to antiviral drugs have been shown to control the HIV epidemic". The immunity occurs due to a mutation in the gene called CCR5. However, the team did not actually reproduce this exact mutation.

"The claim they have reproduced the prevalent CCR5 variant is a blatant misrepresentation of the actual data and can only be described by one term: a deliberate falsehood", said Fyodor Urnov, a scientist at the University of California, Berkeley.

"Approaching this document, I was hoping to see a reflective and mindful approach to gene editing in human embryos".

While the team targeted the right gene, they did not replicate the "Delta 32" variation required, instead creating novel edits whose effects aren't clear.

Climate change could be making birds shrink in size, study finds
In birds, tarsus length is considered the most precise single measure of within-species variation in body size. The number of birds we get each day is highly variable depending on whether it's a big day of migration.

High Winds, Rough Seas Delay SpaceX Resupply Mission
After its launch, the RiTS will be installed via a spacewalk by astronauts, and it will then stay on the outside of the station. The leak detectors have mass spectrometers that can find leaks from the space station, NASA officials said.

Crises Response Tool by Facebook - New Updates and WhatsApp Integration
Facebook is rolling out several new features that use machine learning to deliver more personalized ad experiences to its users. In addition to WhatsApp integration with Crisis Response feature, Facebook is also expanding "Data for Good" tools.

Moreover, CRISPR remains an imperfect tool because it can lead to unwanted or "off-target" edits, making its use in humans hugely controversial.

"It is a ways technically very no longer liable to examine whether or no longer an edited embryo "did no longer demonstrate any off-aim mutations" with out destroying that embryo by inspecting every person of its cells".

Further ethical concerns included that the parents of the babies might have wanted to take part for the wrong reasons.

The mother and father' lack of entry to any sort of fertility therapy might need motivated them to participate within the experiment regardless of the massive dangers to their youngsters, Jeanne O'Brien, a reproductive endocrinologist at Shady Grove Fertility instructed the MIT Know-how Evaluate. "Was this couple free from undue coercion?"

The researchers also seem to have made it hard to find the family by omitting the names of the fertility doctors and by stating a false date of birth.

Chinese scientist is facing backlash from fellow scholars for his inhumane experiment on twins.

To date, no journal has agreed to publish the research, despite He submitting it to a number of publications since past year, including Nature and the JAMA.

Conseillé:



Populaire

China imposes sanctions on US NGOs over Hong Kong rights law
Human Rights Watch said it had received "no communications from the Chinese government" about what the sanctions mean. Protesters are also calling for an independent inquiry into the way police have handled anti-government rallies .

Alanis Morissette sort un nouveau morceau
Le 1 mai prochain, Alanis Morissette sortira son nouvel album Such Pretty Forks in the Road . La vente des billets commencera le 13 décembre.

Tiger Hosts 21st Hero World Challenge
But as a captain he also can take his energy and wisdom and skills and apply it and hopefully draw the best out of his players. I'm looking at how the guys can really perform together. "More than anything, it's been about communication", said Woods.

Disney's 'Star Wars: Galactic Starcruiser' resort will transport you
It comes three months after a land based on a galaxy far, far away opened there. Actors from the most recent Star Wars movies filmed scenes for the ride.

Katy Perry chills with Santa in 'Cozy Little Christmas' video
Christmas is just around the corner with only a couple of weeks to go but we are already getting new Christmas songs. In the later part of the song, Katy Perry seems to enjoy the holiday blessings with all the Christmas creatures.

Huawei to shift research to Canada
The blacklist was imposed by the Trump administration in May, with most USA companies banned from selling to the Chinese company. Huawei founder and CEO Ren Zhengfei gestures as he attends a session of the World Economic Forum in January 2015, in Davos.

Greta Thunberg arrives in Portugal
Greta Thunberg with the Australian family who owns the catamaran and British sailor Nikki Henderson. Thunberg set sail from NY after touring North America, raising awareness about climate change.

Atletico Madrid not punished severely for fans' Griezmann 'die' chants
Barcelona and Real Madrid each have three matches left before they meet each other at the Camp Nou on December 18. Lionel Messi scored a late victor for the Catalans as they leap to top of La Liga on goal difference.

Leroy Merlin en Russie est au bord du scandale ?
La part du réseau Leroy Merlin sur le marché russe de "l'équipement ménager" approche les 20%. Beaucoup d'entre eux se plaignent des manifestations de corruption et des violations de l'éthique des affaires.

Comment devenir webmaster?
Il est amené à rajouter des textes, des images, des vidéos. Il procède également à l’analyse du trafic.