Experts split sharply over experimental Alzheimer's drug

07 Décembre, 2019, 22:24 | Auteur: Yves Courtet
  • Dementia causes stigma

Biogen on Thursday will present highly anticipated data on its experimental Alzheimer's drug aducanumab, which the US biotech company had declared a failure earlier this year.

Biogen will present the additional aducanumab data at the Clinical Trials on Alzheimer's Disease conference in San Diego.

Excitement and skepticism have surrounded aducanumab since its developers stopped studies earlier this year because it didn't seem to be working, then did a stunning about-face in October and said new results suggest it was effective, at a high dose.

However, some experts say that changes during the study and unusual analyses make the results hard to interpret and the risks and benefits of the drug unclear, the AP reported.

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He's not likely to participate in such a review because he was involved in one of the studies, the AP reported.

Some doctors who consult for the drug's developers disagreed.

Dr James Pickett, head of research at Alzheimer's Society, said after the presentation that from the results presented at CTAD "it's not possible to be sure whether people in the early stages of Alzheimer's disease would meaningfully benefit from aducanumab". Dr. Paul Aisen, a dementia specialist at the University of Southern California, said the results overall were "consistent and positive" for benefit at a high dose. Cambridge, Massachusetts-based Biogen is developing it with a Japanese company, Eisai Co. Ltd. Biogen's drug had been seen as potentially offering proof of the long-held theory that removing a toxic protein called beta-amyloid from the brain would slow progression of the disease. But approving a drug that isn't truly effective could expose patients to financial and medical risks and give other drugmakers less incentive to develop better treatments.



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