He had been looking for a deep run at Melbourne Park this year after getting past the opening round for the first time since 2015.
World number 39 Tiafoe had never previously progressed beyond the second round in Melbourne. "I lost to Kevin three times past year, and down a set and a break it looked like he was going to get it for the fourth time".
"But I'm more anxious about winning tennis matches".
"If I play my best I'm hard to beat".
The Swiss star's Australian achievements so far put him on a par with other six-time winners Novak Djokovic and Roy Emerson - although the Australian great's victories all came before the Open era.
His long-time rival and 17-time Grand Slam victor Nadal takes on local hope Matthew Ebden in a night match.
The Spaniard is bidding for his own slice of history by becoming the first man in the Open era, and only the third in history along with Emerson and Rod Laver, to win each Grand Slam on two or more occasions.
In what's been described as the biggest upset at the tournament so far, the second-round encounter lasted just under three hours, with the 20-year-old Tiafoe winning 4-6 6-4 6-4 7-5, setting up a third-round clash with Italian veteran Andreas Seppi.
Another 20-something from the United States threw a scare into another older, more-accomplished top-10 foe, but Mackenzie McDonald couldn't match Tiafoe's upset, losing to No 6 Marin Cilic 7-5 6-7 (9) 6-4 6-4.
"It means the world to me", said the American, who will celebrate his 21st birthday on Sunday and is fresh from playing the mixed teams Hopman Cup in Perth with Serena Williams.
The Croat now plays Spanish 26th seed Fernando Verdasco, who beat Radu Albot of Moldova.
The defending women's champion, Caroline Wozniacki, had an easy win over Johanna Larsson of Sweden 6-1 6-3 in just 66 minutes.
Also through is Greece's Stefanos Tsitsipas, who beat Serb Viktor Troicki 6-3 2-6 6-2 7-5.
"I was trying to stay consistent and as aggressive as I could and I think I served well too", Wozniacki said.
No 5 Sloane Stephens opened the day in Rod Laver Arena with a 6-3 6-1 victory over her junior doubles partner Timea Babos.
Canadian singer and five Grammy Awards victor , Celine Dion , is reportedly planning to pull her acclaimed collaboration with R. The track is from Dion's 1998 holiday album, These Are Special Times , and is written and produced by Kelly.
When he was asked if he had spent Christmas in the United States with Ashley, the 28-year-old said, "We spent time together, yes". Meanwhile, Giovanni was joined on the Lorraine show by fellow Strictly professional dancers Aljaz Skorjanec and Gorka Marquez.
Grace, 22, from Pickford, Essex, was on a round-the-world backpacking trip when she arrived in New Zealand in November. Millane's body was found in West Auckland's Waitākere Ranges on December 9 - a week after she first went missing.
Social services are investigating the children's deaths, although foul play is not suspected to have contributed to the tragedy. Deputies believe when the children entered the freezer, the lid closed and the hasp fell shut, trapping the children inside.
So if you're wanting to get in on this egg-streme world-record, you may want to scramble and like the egg-splosive viral photo. An egg, just a humble chicken egg, has cracked Instagram by becoming the most-liked post of all time.
Cifuentes was working with the US government in 2016 when he first mentioned the bribery allegation to prosecutors. Guzman added that it under Pena Nieto's administration that Guzman was found, detained and extradited.
Sony has been trying to get the film off the ground for quite a while, originally going with veteran actors like Mark Wahlberg . Uncharted is an Arad/Atlas Entertainment Production, with Charles Roven, Avi Arad, Alex Gartner, and Ari Arad producing.
Joe Gibbs Racing co-founder J.D. Gibbs dies at 49
Gibbs was eventually co-chairman of JGR, but began with the organization as a part-time driver and over-the-wall crew member. Gibbs set for all of us", said Steve O'Donnell, NASCAR's chief racing development officer. "I'll miss that the most".
Toddler OK after tumbling from moving vehicle
The shocking incident was captured on Chad Cheddar Mock's dashcam as he was driving behind the mother's auto at about 11.45am. The terrifying footage is a reminder to parents that it's not just the child that needs to be restrained, but their seat too.
Harry Kane May Be Out At Least One Month With Ankle Injury
That makes it likely that Kane will miss Tottenham's league matches against Fulham, Watford, Newcastle United and Leicester City. He added: "They definitely need to get someone in, I would say in this window for a bit of back-up if he's out for a few weeks".