Experimental coronavirus vaccine to be tested in April

01 Mars, 2020, 04:57 | Auteur: Yves Courtet
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As of early Tuesday afternoon, Hong Kong time, there are 80,147 confirmed cases of COVID-19 and 2,699 deaths.

NIH through its National Institute of Allergy and Infectious Diseases (NIAID) in Maryland will launch the first human tests in April. The company described mRNA-1273 as part of its "core prophylactic vaccines modality, which has had six positive Phase 1 clinical readouts across six different vaccines over the past four years". NIAID said it finished manufacturing about 500 vials on February 7.

The big picture: The timing of the drug's development and expected clinical trial is extraordinary. The institute expects by the end of April to start a clinical trial of about 20 to 25 healthy volunteers, testing whether two doses of the shot are safe and induce an immune response likely to protect against infection, NIAID Director Anthony Fauci said in an interview. (MRNA:NASDAQ), which states that it is "pioneering messenger RNA (mRNA) therapeutics and vaccines to create a new generation of transformative medicines", announced that "it has released the first batch of mRNA-1273, the company's vaccine against the novel coronavirus, for human use".

Fauci said that the vaccine is unlikely to be available until next year, even if it is found to be successful.

"The only way you can completely suppress an emerging infectious disease is with a vaccine", Fauci said.

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And although it is still uncertain whether Moderna's vaccine will work, the Kendall Square-based company said the new platform technology built into its Norwood plant has helped accelerate the production of possible vaccines. "We're going to do that in about one and a half to two months".

The move comes as the virus, which originated in China, has been spreading around the globe.

"Going into a Phase One trial within three months of getting the sequence is unquestionably the world indoor record", Fauci told the Journal. This scenario is ideal to gauge if the vaccine can indeed reduce infection rates.

AZ will provide Clover with its pandemic adjuvant system for further evaluation of S-Trimer in preclinical studies, with the aim of rapidly scaling-up and producing large quantities of the potential coronavirus vaccine.


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