Inflammatory disease shows up among young Missouri patients

14 Mai, 2020, 10:08 | Auteur: Anatole Charbonneau
  • Dr. Fatima Kakkar pediatric infectious diseases specialist and a clinician researcher in infectious diseases at Ste Justine's Hospital in Montreal on Wednesday

Has Pediatric Multi-System Inflammatory Syndrome impacted Western New York?

The syndrome can cause life-threatening inflammation in critical organs and appears to be connected to the coronavirus.

As children have been presenting with a wide array of symptoms, physicians have only noted that the condition sometimes seems "Kawasaki-like".

Its symptoms include a rash, high fever, joint pain, and swollen extremities. However, children can also receive an "incomplete" diagnosis if they don't present with every required ailment.

The exact cause of Kawasaki disease remains unknown, but the inflammatory state often arises during or after a viral infection, raising the question of whether COVID-19 could be a potential cause.

That's what Bobby Dean's family did, even though they live in Steuben County, which has only 239 confirmed cases of COVID-19 and is in a part of the state set to start reopening some workplaces on Friday.

Evelina's medical director Dr. Sara Hanna was quoted by the Daily Mirror as saying: "We probably saw the first case in the middle of March".

Children appear to be affected up to six weeks after they have been infected with the virus, which could explain the appearance of the new syndrome several weeks after the peak of United Kingdom cases.

"We will provide a working case definition of what cases look like", the spokesman said. "We're going to have to be very vigilant in the coming weeks".

"This is an inflammatory condition of the blood vessels". Eight of the 10 children were positive for antibodies to SARS-CoV-2 (IgG or IgM or both). Now, the USA has started reporting similar cases.

"So, she does not have the active infection, but it demonstrates that she had it sometime in the past", Buchholz said. "It can't be a coincidence that during this pandemic that we're seeing this syndrome that we've not really seen before", he said.

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Prof David Burgner, a paediatric and infectious diseases doctor, says there is no definitive link between COVID-19 and Kawasaki disease.

What is Kawasaki disease and PIMS-TS?

"There is no blood test".

Health experts believe it could be linked to COVID-19, but cannot definitively say so since not all children with the syndrome have tested positive for COVID-19 although a fair number have.

"While we believe this illness to be rare, seek care is your child has these symptoms - especially if your child has been exposed to someone who had COVID-19", the governor stated. But Portman said it's too soon to tell if Kawasaki disease is actually on the rise as well.

The inflammatory condition, which resembles Kawasaki disease or toxic shock syndrome, has been noted in children in the United Kingdom, Italy and the USA, where 70 children have been diagnosed with it in NY.

"In these patients, do they have antibody against the new coronavirus?".

Children diagnosed with coronavirus are less likely to have severe symptoms.

Saad explained that medical professionals believe that the current onset of Kawasaki symptoms could be a sign that a patient has previously been exposed to COVID-19.

"They are all under investigation", Persichilli said during the state's daily coronavirus briefing in Trenton. The goal is to reduce the inflammation to avoid long-term damage to arteries in the child's body and heart.

"For prospective studies, measuring antibody at the time of presentation, as well as consenting patients for appropriate research samples, will be essential to elucidate the mechanism of this syndrome", they wrote. Between 75 and 100 children are now receiving treatment across the country.



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