Healthcare workers in United Kingdom begin COVID-19 hydroxychloroquine trial

23 Mai, 2020, 01:07 | Auteur: Yves Courtet
  • Antimalarial drug touted by President Trump is linked to increased risk of death in coronavirus patients, study says

Chloroquine or hydroxychloroquine (HCQ), with or without an antibiotic, in hospitalized COVID-19 patients were associated with increased risk of death in the hospital and higher rates of arrhythmias, analysis of outcomes in almost 100,000 patients indicated.

Trump repeatedly has pushed the malaria drugs, and has said he is taking hydroxychloroquine to try to prevent infection or minimize symptoms from the coronavirus.

The biggest risk increase was seen in the group treated with hydroxychloroquine and an antibiotic, where 8 per cent of patients who got the combination developed a heart arrhythmia, compared with 0.3 per cent of those in the comparison group.

Studies indicate that remdesivir, an antiviral that has not yet been approved to treat any disease, may help people with COVID-19 to recover faster, and the drug received FDA emergency use authorization to treat hospitalized patients.

The authors estimated that the drugs put patients at up to 45 percent higher risk of dying from COVID-19 compared with underlying health issues.

When asked about the Lancet study, White House coronavirus taskforce co-ordinator Dr Deborah Birx said the US Food and Drug Administration had been "very clear" about concerns in using the drug as either a coronavirus prevention or as a treatment course.

Dr. Mandeep Mehra, one of the study's authors, said the research shows that the FDA should withdraw that authorization. "Based upon these findings and others, no one should take hydroxychloroquine with or without an antibiotic unless they are in a randomized controlled trial". "That would be an extremely wise decision".

"Randomized clinical trials will be required before any conclusion can be reached regarding benefit or harm of these agents in COVID-19 patients", the paper said.

Jazz’s Bogdanovic to undergo season-ending wrist surgery
Bogdanovic is out for the season, should the 2019-20 campaign resume at some point in the near future. A six-year veteran, Bogdanovic is expected to be ready to play when the 2020-21 season begins.

Scientists test effectiveness of masks on hamsters
In the third experiment, the mask was placed closer to the infected, as if the healthy ones or the infected were wearing masks. In another container connected to the first one, they placed a healthy hamster, thus creating an opportunity for infection.

Corruption scandals in the Israeli Genesis Prize
The prosecutor José Grinda, however, insisted on his maintaining the ‘accused’ status. Mikhail Fridman has a legal case on his hands as well.

Treatment with the medications among patients with Covid-19, either alone or in combination with antibiotics, was linked to an increased risk of serious heart rhythm complications and death.

The researchers looked at data from 671 hospitals across six continents, where 14,888 patients were given either hydroxychloroquine or chloroquine, with or without the antibiotic macrolide, and 81,144 patients were not on any of the treatment regimens.

The researchers warned that hydroxychloroquine should not be used outside of clinical trials.

The big picture: The medical journal's review consisted of 96,000 hospitalized patients diagnosed with the coronavirus in six continents, the largest analysis of medical records on the drug, between December 20, 2019, and April 14, 2020.

Hydroxychloroquine is used to treat lupus and rheumatoid arthritis as well as malaria.

People in any of the four treatment groups were more likely to die during their hospitalization than those not treated. Some proponents of the drugs for COVID-19 argue that they may need to be administered at an earlier stage to be effective. One of the widest-cited studies that touts the drug's effectiveness against the coronavirus included a sample of 97 patients and a control of 84 patients.

Form for signing up for free newsletter.

Professor Mandeep Mehra, lead author of the study and executive director of the Brigham and Women's Hospital Centre for Advanced Heart Disease in Boston in the United States, said: "This is the first large scale study to find statistically robust evidence that treatment with chloroquine or hydroxychloroquine does not benefit patients with Covid-19". Retail sales of hydroxychloroquine reportedly soared in March, the month Trump called the drug a "game changer" for treating coronavirus.

Conseillé:

  • Jets, QB Joe Flacco agree to terms on 1-year deal

    Jets, QB Joe Flacco agree to terms on 1-year deal

    The New York Jets are adding a big name to their roster, signing Joe Flacco to a one-year contract. He had been released by the Broncos earlier in the offseason and underwent neck surgery in April.
    Le Tribunal de Paris déboute Amiens, Toulouse et l’OL

    Le Tribunal de Paris déboute Amiens, Toulouse et l’OL

    L'ensemble du club, de ses partenaires et de ses supporters maintiennent leur Union sacrée pour notre territoire! Ce qui ne change donc à ses yeux " en aucun cas la nature et le fondement " de ses recours.
    Trump declares places of worship 'essential,' setting up standoff with governors

    Trump declares places of worship 'essential,' setting up standoff with governors

    Despite many churches holding services online, President Trump remarked Thursday that it was not the same as attending in person. He said if governors don't abide by his request, he will "override" them, though it is unclear what authority he has to do so.
  • Pat Riley Releases Reverential Statement on Passing of Jerry Sloan

    Pat Riley Releases Reverential Statement on Passing of Jerry Sloan

    He coached franchise icons Karl Malone, John Stockton and Mark Eaton out of the gates. Former Utah Jazz coach Jerry Sloan has passed away at the age of 78.
    Canadians should wear masks to protect others when in public: Tam

    Canadians should wear masks to protect others when in public: Tam

    That understanding has changed, as it is now known people without symptoms can transmit the virus to others. He was first seen wearing a mask in public during a May 6 Canadian Armed Forces repatriation ceremony.
    L'ancien joueur et entraîneur Jerry Sloan est décédé — NBA

    L'ancien joueur et entraîneur Jerry Sloan est décédé — NBA

    On se souvient notamment des finales mémorables de 1997 et 1998 perdues face aux Chicago Bulls de Michael Jordan . Après trois saisons sur le banc des Bulls, Jerry Sloan dirige le Utah Jazz à partir de 1988.
  • Brian Austin Green et Megan Fox divorcent après dix ans de mariage

    Brian Austin Green et Megan Fox divorcent après dix ans de mariage

    News, les deux ne sont effectivement pas de "simples amis" et se sont rapprochés "il y a un petit temps", entretenant une idylle. Le couple, qui était ensemble depuis plus de 15 ans et a trois enfants, a décidé de se séparer.

    Comment devenir webmaster?

    Il est amené à rajouter des textes, des images, des vidéos. Il procède également à l’analyse du trafic.

    Votre voiture doit être dans un état impeccable

    En ce qui concerne la sécurité, le choix des pneus parfaitement adaptés est extrêmement. Mais tout d’abord, vous devez savoir où trouver les pièces compatibles avec votre voiture.
  • San Siro va bien être détruit

    Divisé sur cette entreprise, le conseil municipal avait fait appel à l'avis de la commission régionale en charge du patrimoine. Après plusieurs réaménagements, il ne reste qu'un petit vestige de la partie la plus ancienne du stade, construite en 1926.
    Premier wants Ontario to be a global leader on COVID-19 research

    Premier wants Ontario to be a global leader on COVID-19 research

    The Ontario government announced funding for a number of research projects in the province aimed at fighting COVID-19 . Additionally, Ontario is leading the country with 22 clinical trials investigating COVID-19 vaccines and treatments.
    Antarctica's Green Snow Mapped From Space

    Antarctica's Green Snow Mapped From Space

    The blooms the researchers mapped can remove as much carbon from the atmosphere as driving a auto a million miles would create. In these areas, the temperature rises to a little over zero degrees Celsius in the Summer months (November-February).


Populaire

Agency that oversees Coliseum says A's haven't paid rent
Authority board member Ignacio de LaFuente blasted the A's, saying, "it's just an excuse to try to not pay when the city needs the money the most".

Khashoggi's family 'forgives' his killers
Therefore we the sons of the Martyr's Jamal Khashoggi announce pardoning those who killed our father, seeking reward God almighty. But Salah, Khashoggi's eldest son, was the only sibling who meant to carry on living in Saudi Arabia , the newspaper said.

Machine Gun Kelly Releases Visual For "Bloody Valentine" Starring Megan Fox
Megan Fox is still proud of her "family name" despite the actress' current split from husband Brian Austin Green . Their relationship has been subject to split rumors before, with Fox filing for divorce in 2015.

Une Italienne remporte une peinture de Picasso dans une tombola caritative française
Le billet a été acheté en décembre par un habitant de Vintimille et offert à la gagnante, ont fait savoir les organisateurs. C'est donc 4,2 millions d'euros (6,3 millions de dollars canadiens) qui iront financer le projet de CARE.

Naomi Osaka devient l'athlète féminine la mieux rémunérée de l'histoire
Sharapova détenait, de son côté, le précédent record pour une athlète féminine avec 29,7 millions de dollars amassés en 2015. Et la nouvelle star du sport mondial est...

New details emerge about Mary Kate Olsen's marriage breakdown
Apparently Sarkozy, who has two grown children with ex-wife Charlotte Bernard , didn't want to have any more kids, while Olsen did.

National Football League testing modified facemasks to protect players from coronavirus
Oakley is already contracted by the National Football League to provide visors that some players use on their face masks. The protection face masks offer, however, is for those who could be infected by the person wearing the mask itself.

Warning signs of Nova Scotia mass shooter's paranoia in warrant document
The rampage involved multiple shootings with unlicensed semi-automatic weapons and arson attacks on homes using gasoline. She described how he had a relationship with someone in the RCMP and had one of his uniforms, though it didn't fit.

Why the Government of National Accord in Libya is illegitimate
The most famous paramilitary organization that is part of the National Security Service of GNA is the «RADA» group. He is one of the main opponents of the Muslim Brotherhood in the region and one of the most famous fighters against terrorism.

Fils de légende de la Formule 1 a dépassé son père
Nul doute qu’elle offrira à Mika la meilleure option pour poursuivre sa carrière dans le sport automobile. Et il n'est pas Andrei Arshavin, pour répondre à la question sur les attentes facilement et naturellement.