Why are some COVID-19 infected people asymptomatic?

29 Octobre, 2020, 20:39 | Auteur: Yves Courtet
  • Lilly antibody drug fails in study of hospitalized Covid-19 patients

The Branchburg site manufactures a number of products for Eli Lilly, including bamlanivimab (LY-CoV555) a monoclonal antibody Lilly is developing as both a monotherapy and a combination therapy against COVID-19.

Last week, Lilly confirmed that the ACTIV-3 trial on COVID-19 patients who were very sick and in hospital had stopped because it wasn't effective.

The treatments belong to a class of drugs called monoclonal antibodies that are manufactured copies of antibodies created by the body to fight against an infection.

That is the same compound treatment President Trump received after contracting the coronavirus.

The drug recognizes the virus once a person is infected and attaches to the spike-shaped protein the virus uses to infect cells, preventing the pathogen from spreading throughout the body.

In addition, Reuters reported that USA drug inspectors uncovered serious quality control problems at an Eli Lilly plant that is ramping up to make its antibody therapy.

Overall, patients in the antibody group saw 99.97 percent of their viral loads eliminated compared to those who were given a placebo.

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The U.S. government will pay $375 million for that first delivery.

The U.S. government also has the option to purchase up to an additional 650,000 vials for $812.5 million, the U.S. Department of Health and Human Services said in a statement.

The study of the monoclonal antibody called bamlanivimab was initially paused by the company on October 13 out of "an abundance of caution", because of a potential safety concern.

The antibody therapy is similar to a drug from Regeneron that was given to Trump during his bout with COVID-19.

Independent monitors had paused enrollment in the study two weeks ago because of a possible safety issue.

Eli Lilly is seeking emergency authorization to treat coronavirus patients outside of the hospital with the antibody outside of the hospital.

But on Monday, the National Institute of Allergy and Infectious Diseases, which sponsors the study, said a closer look found no safety problem but a low chance that the drug would prove helpful for hospitalized patients.

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