United Kingdom approves trial deliberately exposing volunteers to virus

19 Février, 2021, 19:58 | Auteur: Auguste Feret

British regulators have approved the world's first coronavirus human challenge trial, in which volunteers will be deliberately exposed to the virus to study how the infection spreads.

The study is due to begin in the next few weeks and will be delivered by experts from the Government's Vaccines Taskforce, Imperial College London, the Royal Free London NHS Foundation Trust and the company hVIVO, which has pioneered viral human challenge models.

The study will recruit up to 90 healthy volunteers between the ages of 18 and 30 with no previous history or symptoms of Covid-19, no underlying health conditions and no known adverse risk factors for Covid-19 such as diabetes or being overweight.

The aim of the human challenge trial is to establish the smallest amount of virus needed to cause infection. Medics and scientists then closely monitor the effect on volunteers 24 hours per day to see exactly how the vaccine works and to identify any side effects.

The volunteers, who are being encouraged to come forward for the study, will be between 18 and 30 and will be exposed to the variant circulating in the United Kingdom since March 2020. It is hard to study the efficacy of vaccines as those in traditional trials may not be naturally exposed to the virus, whereas human challenge studies deliberately infect volunteers with Covid-19.

Volunteer hopefuls will register for the trials.

Volunteers will receive around £4,500 (€5,181) to participate in the study which will involve some 17 days of quarantine and follow-ups over 12 months.

Catchpole said: "The main benefits are that this allows us to test new vaccines that are required to deal with the new variations of Covid-19, ie. the second generation of vaccines which will be required later this year or early next".

There are certain limitations of HCTs, since they can not be conducted for diseases that have a high case fatality rate or for diseases for which no course of treatment is available.

Facebook bans Australian users from viewing and sharing news
After strong criticism, Facebook eventually restored government pages related to the pandemic and other important information. These included what Facebook described as its investments in Australian news companies that amount to millions of dollars.

US life expectancy sees biggest decline since World War II
Conversely, the gap between Hispanic Americans and white Americans decreased by 37%, from 3 to 1.9 years, according to the report. Black people now lag white people by six years in life expectancy, reversing a trend that had been narrowing the gap since 1993.

Melbourne's 5-Day Lockdown to End With Cluster Under Control
Nearly 40,000 test results were received in the 24 hours to midnight yesterday and there are 25 active cases across the state. But Victorian Health Minister Martin Foley warned the latest COVID-19 cluster wasn't over yet.

The aim of the study is to allow doctors to gain a better understanding of Covid-19 and help support the pandemic response by aiding vaccine and treatment development.

Researchers say that younger adults have immune systems which are different from older adults and people who are more at risk of severe Covid-19, and so, it is not always possible to directly extrapolate findings from this study situation to patients in the community.

Only vaccines that "have proven to be safe in clinical trials" will be used.

In the past, human challenge studies have played important roles in accelerating the development of treatments for diseases including malaria, typhoid, cholera, norovirus and flu.

In this way, the participants are "challenged" by the virus.

"We expect these studies to offer unique insights into how the virus works and help us understand which promising vaccines offer the best chance of preventing the infection", he said.

The trials will be conducted in "secure clinical research facilities" that are "specifically created to contain the virus", according to the government, which stressed that the safety of trial participants was paramount.

The virus researchers will use in the trials was produced at Great Ormond Street Hospital.



Today, US officially rejoins Paris Climate accord, 107 days after it quit
One fear was that other nations would follow America in abandoning the climate fight, but none did, Ms Figueres said. John Kerry, President Joe Biden's administration's climate envoy, sounded the alarm on an upcoming climate crisis .

Harry and Meghan not returning as working members of Royal Family
Meghan was also handed several honorary roles after she Wednesday Harry in a fairytale ceremony at Windsor Castle in May, 2018. In a statement, Buckingham Palace added that Harry and Meghan will hand over various patronages and honorary military titles.

Un nouveau contrat européen avec Moderna — Vaccin Covid
La Commission européenne a approuvé un nouveau contrat de commande de vaccins contre le coronavirus avec l'Américaine Moderna . Il y a également une option de 150 millions de doses supplémentaires en 2022, a ajouté la société de biotechnologies.

Mars 2020 : comment regarder en direct l'atterrissage de Perseverance sur Mars
Après les Émirats arabes unis et la Chine, c'est au tour des États-Unis de rejoindre la planète Mars . La mission américaine est la troisième à approcher de Mars depuis le début de l'année 2021.

'A dour political hack': Trump levels stinging criticism at Mitch McConnell
McCarthy and Trump discussed the midterm elections in 2022, according to a readout provided by his Save America PAC. Donald Trump talks to the press as Senate Majority Leader Mitch McConnell looks on in January 2019.

Bob Dole Announces Stage-Four Lung Cancer Diagnosis
Health troubles continue for former long-serving Kansas senator Bob Dole , who's been diagnosed with Stage 4 lung cancer . He served for 27 years as a United States senator from Kansas, including two stints as the Senate majority leader.

European Union adding anti-variant clauses to Covid vaccine supply deals, sources say
Fortin said Moderna, which has already delivered 500,000 doses, will deliver a reduced shipment of 168,000 doses next week. The US drugs maker was due to ship the vaccines to the bloc in December, according to European Union officials.

Provincial COVID-19 positivity rate jumped on Tuesday
On Monday, Newfoundland and Labrador confirmed 298 active cases are tied to the variant first found in the United Kingdom . The Enhanced COVID-19 Business Benefit is meant to provide additional support in cases where federal programs fall short.

Conservatives Mourn Over Rush Limbaugh's Death of Cancer
Limbaugh announced in February past year he had advanced lung cancer. His wife Kathryn announced the death today on his radio show.

FBI, US Attorney probing Cuomo's nursing home death scandal
The governor also accused Kim of being "unethical" for backing nail salon owners as lawmakers discussed safety and wage reforms of the industry in 2015.